The Combined DNA Index System (CODIS), managed by the Federal Bureau of Investigation (FBI), is the FBI’s program of support for criminal justice DNA databases, as well as the software used to run these databases. CODIS operates on three levels: The Local DNA Index System (LDIS), which is used by city and county laboratories, the State DNA Index System (SDIS) where profiles from laboratories across the State can be compared, and the National DNA Index System (NDIS), where profiles from laboratories across the country can be compared. For more info visit the FBI CODIS FAQ Page.